Antibiotic inhibition of ribosome function

Antibiotic inhibition of ribosome function

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Bibliographic Details
Other Authors: Wilson, Daniel N. (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2008.
Series:Henry Stewart talks. Biomedical & life sciences collection. Mechanisms of ribosome function : insights into protein synthesis.
Subjects:
Protein Biosynthesis.
Ribosomal Proteins.
Ribosomes.
Online Access:https://hstalks.com/bs/812/
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Table of Contents:
  • Contents: Overview of antibiotics that target the ribosome
  • Different mechanisms by which translation initiation inhibitors, such as kasugamycin and edeine, perturb initiator tRNA binding
  • Structural insight into how the thiopeptide class of antibiotics, such as thiostrepton and micrococcin, inhibit stable binding of translation factors, such as EF-G, to the ribosome
  • Mechanism by which drugs, such as chloramphenicol and macrolides inhibit the peptidyltransferase reaction
  • How species specific differences in antibiotic interaction sites between different organisms can have a dramatic influence on drug binding.

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