Protein folding and misfolding from theory to therapy /
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| Format: | Electronic Video |
| Language: | English |
| Published: |
London :
Henry Stewart Talks,
2007.
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| Series: | Henry Stewart talks. Biomedical & life sciences collection. Protein folding, aggregation and design : concepts, experiments, theories and mechanisms.
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| Subjects: | |
| Online Access: | https://hstalks.com/bs/429/ Series |
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Table of Contents:
- Contents: Protein nature, folding and complexity
- Folding in a cellular environment
- The underlying principles of folding
- Native and transition states
- Exploring the energy surface
- The folding of lysozyme
- The consequences of protein misfolding
- The relationship between folding and disease
- Protein deposition diseases
- Protein aggregates in amyloid diseases
- Amyloidogenic mutations of lysozyme
- Mechanism of amyloid formation
- Structure of the amyloidogenic intermediate
- Amyloid formation by lysozyme in vivo
- SH3 domain of PI3 kinase
- Model of an amyloid fibril
- The underlying origins of amyloid disease
- Generic toxicity of amyloid aggregates
- Cellular defences against aggregation
- Evolutionary design of proteins
- "Post-evolutionary" diseases.
Protein folding