Mechanism-based therapies for heart failure and cardiac arrhythmias
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| Other Authors: | |
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| Format: | Electronic Video |
| Language: | English |
| Published: |
London :
Henry Stewart Talks,
2007.
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| Series: | Henry Stewart talks. Biomedical & life sciences collection. Calcium signaling I.
Henry Stewart talks. Biomedical & life sciences collection. Calcium signaling II. |
| Subjects: | |
| Online Access: | https://hstalks.com/bs/427/ Series (Calcium signaling 1) Series (Calcium signaling 2) |
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Table of Contents:
- Contents: Introduction to excitation-contraction coupling
- History of the field of EC coupling
- Introduction to the ryanodine receptor/calcium release channel (RyR2)
- Mechanisms that regulate the RyR2 channel during stress
- Defective regulation of RyR2 in heart failure
- Evidence that diastolic sarcoplasmic reticulum (SR) calcium leak causes heart failure and arrhythmias in vivo
- Novel therapeutic approaches to treating heart failure and preventing sudden cardiac death by fixing the leak in RyR2 channels.
Ryanodine receptors and cardiac function