EGF receptor family targets for cancer therapeutics /
Saved in:
| Other Authors: | |
|---|---|
| Format: | Electronic Video |
| Language: | English |
| Published: |
London :
Henry Stewart Talks,
2007.
|
| Series: | Henry Stewart talks. Biomedical & life sciences collection. Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease.
|
| Subjects: | |
| Online Access: | https://hstalks.com/bs/456/ Series |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Add Tag MARC
| LEADER | 00000ngm a2200000 a 4500 | ||
|---|---|---|---|
| 001 | HST1074_1_2 | ||
| 003 | UkLoHST | ||
| 006 | m c | ||
| 007 | cr|cna|||a|||| | ||
| 007 | vz|czazum | ||
| 008 | 080121s2007 enk|||||||||||s|||v|eng d | ||
| 028 | 5 | 0 | |a 1074 |b Henry Stewart Talks |
| 035 | |a (UkLoHST)456 | ||
| 035 | |a (UkLU-K)AC000390284 | ||
| 040 | |a UkLU-K |b eng |c UkLU-K | ||
| 100 | 1 | |a Burgess, Antony, |d 1946- |4 spk |9 109857 | |
| 245 | 1 | 0 | |a EGF receptor family |h [electronic resource] : |b targets for cancer therapeutics / |c Tony Burgess. |
| 260 | |a London : |b Henry Stewart Talks, |c 2007. | ||
| 300 | |a 1 online resource (1 streaming video file (45 min.) : |b color, sound). | ||
| 490 | 1 | |a Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease, |x 2056-452X | |
| 500 | |a Animated audio-visual presentation with synchronized narration. | ||
| 500 | |a Title from title frames. | ||
| 505 | 0 | |a Contents: The association of the Epidermal Growth Factor Receptor (EGFR) with the tumorigenic state -- The four related members of the EGFR family (EGFR, erbB2, erbB3 and erbB4) -- Signaling of the activated receptors as either homo- or heteromeric oligomers -- Activation of the EGFR by excess ligand stimulation, receptor over-expression and/or mutation in many carcinomas -- Utility of antibodies and receptor kinase inhibitors which interfere with signaling from the EGFR family as agents in cancer therapy -- The three-dimensional structures for the extracellular domains of EGFR, erbB2, erbB3 and erbB4 and the discovery that EGFR, erbB3 and erbB4 undergo major conformational transitions when interacting with their ligands -- Development of antibodies (mab806) which reduce tumor formation from cells expressing either truncated D2-7 EGFR or over-expressed EGFR by binding to the receptor in a region normally masked by the dimerization of the EGFR extracellular domain -- Use of EGFR antagonists or inhibitors to increase tumor killing by cytotoxic anti-cancer drugs and/or radiation -- Improvement of tumor killing by combining EGFR antagonists and EGFR kinase inhibitors. | |
| 506 | |a Access restricted to subscribers. | ||
| 538 | |a Mode of access: World Wide Web. | ||
| 650 | 2 | |a Cells. |9 109858 | |
| 650 | 2 | |a Receptor Protein-Tyrosine Kinases. |9 109859 | |
| 650 | 2 | |a Receptor, Epidermal Growth Factor. |9 109860 | |
| 650 | 2 | |a Signal Transduction. |9 109861 | |
| 650 | 2 | |a Tumor Cells, Cultured. |9 109862 | |
| 830 | 0 | |a Henry Stewart talks. |p Biomedical & life sciences collection. |p Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease. |9 109863 | |
| 856 | 4 | 0 | |u https://hstalks.com/bs/456/ |
| 856 | 4 | 2 | |u https://hstalks.com/bs/p/38/ |3 Series |
| 999 | |c 215824 |d 215823 | ||
The epidermal growth factor receptor family roles in development and cancer /