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Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by chan...

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Bibliografiske detaljer
Main Authors: Tveito, Aslak (Author), Lines, Glenn T. (Author)
Institution som forfatter: SpringerLink (Online service)
Format: Electronisk eBog
Sprog:engelsk
Udgivet: Cham : Springer International Publishing : Imprint: Springer, 2016.
Serier:Lecture Notes in Computational Science and Engineering, 111
Fag:
Mathematics.
Computer graphics.
Computer mathematics.
Computational Science and Engineering.
Biomedicine general.
Computer Imaging, Vision, Pattern Recognition and Graphics.
Online adgang:http://dx.doi.org/10.1007/978-3-319-30030-6
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Indholdsfortegnelse:
  • Preface
  • Background: Contents and Method
  • One-dimensional calcium release
  • Models of open and state blockers
  • Two-dimensional calcium release
  • Computing theoretical drugs in the two-dimensional case
  • Generalized systems
  • Calcium-induced calcium release
  • Numerical release for CICR
  • A prototypical model of an ion channel
  • Inactivated ion channels
  • A simple model of the sodium channel
  • Mutations affecting the mean open time
  • The burst mode
  • Whole sale action potentials
  • .

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