Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models
Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by chan...
שמור ב:
Main Authors: | , |
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מחבר תאגידי: | |
פורמט: | אלקטרוני ספר אלקטרוני |
שפה: | אנגלית |
יצא לאור: |
Cham :
Springer International Publishing : Imprint: Springer,
2016.
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סדרה: | Lecture Notes in Computational Science and Engineering,
111 |
נושאים: | |
גישה מקוונת: | http://dx.doi.org/10.1007/978-3-319-30030-6 |
תגים: |
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תוכן הענינים:
- Preface
- Background: Contents and Method
- One-dimensional calcium release
- Models of open and state blockers
- Two-dimensional calcium release
- Computing theoretical drugs in the two-dimensional case
- Generalized systems
- Calcium-induced calcium release
- Numerical release for CICR
- A prototypical model of an ion channel
- Inactivated ion channels
- A simple model of the sodium channel
- Mutations affecting the mean open time
- The burst mode
- Whole sale action potentials
- .