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Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models

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Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by chan...

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Bibliographic Details
Main Authors: Tveito, Aslak (Author), Lines, Glenn T. (Author)
Corporate Author: SpringerLink (Online service)
Format: Electronic eBook
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2016.
Series:Lecture Notes in Computational Science and Engineering, 111
Subjects:
Mathematics.
Computer graphics.
Computer mathematics.
Computational Science and Engineering.
Biomedicine general.
Computer Imaging, Vision, Pattern Recognition and Graphics.
Online Access:http://dx.doi.org/10.1007/978-3-319-30030-6
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Table of Contents:
  • Preface
  • Background: Contents and Method
  • One-dimensional calcium release
  • Models of open and state blockers
  • Two-dimensional calcium release
  • Computing theoretical drugs in the two-dimensional case
  • Generalized systems
  • Calcium-induced calcium release
  • Numerical release for CICR
  • A prototypical model of an ion channel
  • Inactivated ion channels
  • A simple model of the sodium channel
  • Mutations affecting the mean open time
  • The burst mode
  • Whole sale action potentials
  • .

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