Phosphoserine/threonine binding domains molecular integrators of protein kinase signaling in cell cycle control and cancer /

Phosphoserine/threonine binding domains molecular integrators of protein kinase signaling in cell cycle control and cancer /

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Bibliographic Details
Other Authors: Yaffe, Michael B. (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2008.
Series:Henry Stewart talks. Biomedical & life sciences collection. Chemical biology : the role of chemistry in our fundamental understanding of biology.
Subjects:
Biology.
Chemistry.
Online Access:https://hstalks.com/bs/941/
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Table of Contents:
  • Contents: Protein phosphorylation
  • Historical perspective on signaling by tyrosine kinases
  • The human kinome
  • How can phosphorylation control enzyme activity
  • The new 'dogma' of signal transduction by serine/threonine kinases
  • New phospho-binding domains
  • Polo family kinases together with cyclin-dependent kinases play many roles throughout mitosis
  • Architecture of polo-like kinases
  • Structural basis for phospho-dependent binding
  • What does the polo-box domain do in cells
  • A proteomic approach to identifying new phospho-Ser/Thr-binding domains
  • The DNA damage response pathway
  • BRCA1
  • Cancer associated mutations.

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