Nuclear receptors superfamily structural insights into function /

Nuclear receptors superfamily structural insights into function /

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Bibliographic Details
Other Authors: Moras, Dino (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2007.
Series:Henry Stewart talks. Biomedical & life sciences collection. World of hormones : molecular and physiological insights.
Subjects:
Hormones.
Receptors, Cytoplasmic and Nuclear.
Online Access:https://hstalks.com/bs/485/
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Table of Contents:
  • Contents: Signal transduction and transcriptional regulation
  • Cofactor binding and transcriptional activation
  • The modular organization of nuclear hormone receptors
  • The DNA binding domain
  • The ligand binding domain
  • Sequence/structure to function
  • The oligomeric state
  • Allosteric control through post-translational modifications
  • Communication pathways in NRs
  • Ligand binding: specificity and adaptability
  • The retinoid receptors: RXR and RAR
  • Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor
  • Binding to coactivators and corepressors: the signature motifs
  • Ligand dependent (de)activation: agonists and antagonists
  • Estrogen receptor
  • The vitamin D receptor.

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