Chemistry of peptide bond formation
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| Other Authors: | |
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| Format: | Electronic Video |
| Language: | English |
| Published: |
London :
Henry Stewart Talks,
2008.
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| Series: | Henry Stewart talks. Biomedical & life sciences collection. Mechanisms of ribosome function : insights into protein synthesis.
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| Subjects: | |
| Online Access: | https://hstalks.com/bs/803/ Series |
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Table of Contents:
- Contents: Fundamental processes during protein synthesis
- Peptidyl transfer catalysis by RNA-rich active site
- Ribosome structure solution provided new insights
- Peptide bond formation and peptide release
- Active site of the ribosome
- Universally conserved nucleotides of the active site
- Affinity tag purification of mutant ribosomes
- Active site mutations and rates of peptidyl transfer
- A-site substrates: tRNA vs. puromycin
- "Uninduced" state of ribosome and P-site substrate
- A-site substrates-induced conformational changes
- Peptide release activity of variant ribosomes
- RF catalysis in the large subunit
- RF conserved amino acids in bacteria
- Consequences of RF1 site-directed mutations
- Nucleophile partitioning
- Mutants that lost water specificity
- RF components functioning in activating hydrolysis
- Regulation of translation post-initiation.
Chemistry of peptide bond formation