Translocation movement of tRNA and mRNA through the ribosome /

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Translocation movement of tRNA and mRNA through the ribosome /

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Bibliographic Details
Other Authors:	Noller, Harry F. (Speaker)
Format:	Electronic Video
Language:	English
Published:	London : Henry Stewart Talks, 2008.
Series:	Henry Stewart talks. Biomedical & life sciences collection. Mechanisms of ribosome function : insights into protein synthesis.
Subjects:	Protein Biosynthesis. Ribosomal Proteins. Ribosomes.
Online Access:	https://hstalks.com/bs/807/ Series
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Table of Contents:

Contents: Ribosomes and translation
Molecular composition of the ribosome
Why is the ribosome so big?
The mRNA channel in the 30S subunit
Positions of tRNA in the A-, P- and E-sites
Structural dynamics of the ribosome during translocation
The hybrid states elongation cycle
tRNA binding during its movement through the ribosome
The 70S ribosome
Distortion of tRNA structure by the ribosome
The ratchet model
Cryo-EM experiment
Inferred relationship between ratcheting and hybrid states
FRET changes
Intersubunit movement
Testing the ratchet model for translocation
Translocation assay
What defines the mechanism of translocation
Sparsomycin
The energetics of translocation
E-site tRNA
The ribosome is a molecular machine.