Antibiotic inhibition of ribosome function
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Format: | Electronic Video |
Language: | English |
Published: |
London :
Henry Stewart Talks,
2008.
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Series: | Henry Stewart talks. Biomedical & life sciences collection. Mechanisms of ribosome function : insights into protein synthesis.
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Subjects: | |
Online Access: | https://hstalks.com/bs/812/ Series |
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Table of Contents:
- Contents: Overview of antibiotics that target the ribosome
- Different mechanisms by which translation initiation inhibitors, such as kasugamycin and edeine, perturb initiator tRNA binding
- Structural insight into how the thiopeptide class of antibiotics, such as thiostrepton and micrococcin, inhibit stable binding of translation factors, such as EF-G, to the ribosome
- Mechanism by which drugs, such as chloramphenicol and macrolides inhibit the peptidyltransferase reaction
- How species specific differences in antibiotic interaction sites between different organisms can have a dramatic influence on drug binding.