The interaction of antibiotics with the large ribosomal subunit from Haloarcula Marismortui
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| Format: | Electronic Video |
| Language: | English |
| Published: |
London :
Henry Stewart Talks,
2008.
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| Series: | Henry Stewart talks. Biomedical & life sciences collection. Mechanisms of ribosome function : insights into protein synthesis.
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| Subjects: | |
| Online Access: | https://hstalks.com/bs/811/ Series |
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Table of Contents:
- Contents: Introduction to a paradox: how can a universally conserved cellular component be a target for pharmacologically useful antibiotics?
- Introduction to ribosome structure
- Antibiotic binding sites cluster in the ribosome
- The source of the species specificity of antibiotics that interact with the A-site cleft
- How macrolides interact with the ribosome
- The structural consequences of mutations that make ribosomes resistant to macrolides
- The toxicity of macrolides is not well understood
- 13-deoxytedanolide, a novel macrolide with novel species specificity that binds to a novel site in the ribosome.
The interaction of antibiotics with the large ribosomal subunit from Haloarcula Marismortui