CD44 genetic deletion enhances and CD44 antibody targeting attenuates autoimmune inflammation
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Format: | Electronic Video |
Language: | English |
Published: |
London :
Henry Stewart Talks,
2007.
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Series: | Henry Stewart talks. Biomedical & life sciences collection. Autoimmunity : etiology, pathogenesis, clinical manifestation and diagnostic methodologies.
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Subjects: | |
Online Access: | https://hstalks.com/bs/213/ Series |
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Table of Contents:
- Contents: CD44 and RHAMM (receptor for hyaluronan-mediated motility) are cell adhesion and cell homing receptors
- Cell migration
- Generation of different CD44 isoforms
- RHAMM also supports cell motility and is engaged in intracellular signalling
- Collagen-induced arthritis and type 1 diabetes are CD44-dependent pathologies
- Molecular redundancy
- CD44 targeting by anti-CD44 mAb may eradicate not only malignant cells and destructive inflammatory cells but also CD44-expressing normal cells which are committed to physiological functions.