CD44 genetic deletion enhances and CD44 antibody targeting attenuates autoimmune inflammation

CD44 genetic deletion enhances and CD44 antibody targeting attenuates autoimmune inflammation

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Bibliographic Details
Other Authors: Golan, Itahk (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2007.
Series:Henry Stewart talks. Biomedical & life sciences collection. Autoimmunity : etiology, pathogenesis, clinical manifestation and diagnostic methodologies.
Subjects:
Autoimmune Diseases.
Autoimmunity.
Research.
Online Access:https://hstalks.com/bs/213/
Series
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Table of Contents:
  • Contents: CD44 and RHAMM (receptor for hyaluronan-mediated motility) are cell adhesion and cell homing receptors
  • Cell migration
  • Generation of different CD44 isoforms
  • RHAMM also supports cell motility and is engaged in intracellular signalling
  • Collagen-induced arthritis and type 1 diabetes are CD44-dependent pathologies
  • Molecular redundancy
  • CD44 targeting by anti-CD44 mAb may eradicate not only malignant cells and destructive inflammatory cells but also CD44-expressing normal cells which are committed to physiological functions.

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