GM2 gangliosidosis

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GM2 gangliosidosis

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Bibliographic Details
Other Authors:	Mahuran, Don (Speaker)
Format:	Electronic Video
Language:	English
Published:	London : Henry Stewart Talks, 2007.
Series:	Henry Stewart talks. Biomedical & life sciences collection. Protein epidemiology.
Subjects:	Tay-Sachs disease. beta-N-Acetylhexosaminidases > chemistry. Dimerization. G(M2) Ganglioside. Gangliosidoses, GM2 > genetics. Gangliosidoses, GM2 > metabolism. Gangliosidoses, GM2 > physiopathology. Hexosaminidase A. Lysosomes. Sandhoff Disease > genetics. Sandhoff Disease > metabolism. Substrate Specificity. Tay-Sachs Disease > genetics. Tay-Sachs Disease > metabolism.
Online Access:	https://hstalks.com/bs/53/ Series
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Table of Contents:

Contents: GM2 gangliosidosis: the disease and the associated system of beta-hexosaminidase isozymes
Structure-function relationships
What have naturally occurring mutations told us?
Why is dimerization necessary for activity if both subunits have active sites?
What is the basis for the substrate-specificity differences between the active sites of the two subunits?
Why can only heterodimeric hexosaminidase A hydrolyze GM2 ganglioside?.