Small interfering RNA induced transcriptional gene silencing in human cells

Small interfering RNA induced transcriptional gene silencing in human cells

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Bibliographic Details
Other Authors: Morris, Kevin V. (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2007.
Series:Henry Stewart talks. Biomedical & life sciences collection. RNA interference : principles and applications.
Subjects:
Cells.
Gene Silencing.
RNA Interference.
RNA, Small Interfering.
Transcription, Genetic.
Online Access:https://hstalks.com/bs/651/
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Table of Contents:
  • Contents: How siRNAs mediate transcriptional gene silencing (TGS) in human cells
  • Histone methylation
  • Dependency on active RNA polymerase II mediated transcription
  • siRNA-mediated TGS
  • H3K9 and H3K27 methylation of the targeted EF1A promoter
  • Nuclear specific delivery of the siRNA
  • Antisense strand-specific siRNA-mediated TGS of EF1A
  • Targeting of the U3 region of the HIV-1 LTR/promoter
  • Antisense strand of siRNA EF2 interacts with FLAG-tagged DNMT3A and the tri-methylated H3K27 methyl mark
  • siRNA mediated targeting of genomic regions
  • RNA Pol-II function
  • Transcriptional gene silencing in human cells.

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