Novel proteins from designed combinatorial libraries
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| Other Authors: | |
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| Format: | Electronic Video |
| Language: | English |
| Published: |
London :
Henry Stewart Talks,
2007.
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| Series: | Henry Stewart talks. Biomedical & life sciences collection. Protein folding, aggregation and design : concepts, experiments, theories and mechanisms.
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| Subjects: | |
| Online Access: | https://hstalks.com/bs/443/ Series |
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Table of Contents:
- Contents: Novel proteins can be devised using either rational/computational approaches or random/combinatorial methods
- Description of a hybrid approach that combines rational and combinatorial methods: libraries of novel proteins
- Combinatorial diversity
- Random vs. focused libraries
- Amphiphilic alpha-helices and beta-strands
- Binary patterning of polar and non-polar amino acids
- Genetic encoding of combinatorial mixtures of polar and non-polar amino acids
- Design of libraries of novel 4-helix bundles
- Library construction and expression in vivo
- Dynamic vs. wellordered protein structures
- Second generation libraries
- Biophysical characterization
- Solution structure of native-like 4-helix bundle proteins from designed libraries
- Functionally active proteins including cofactor binding proteins, peroxidases and esterases
- Designed libraries of beta sheet proteins: amyloid-like fibrils, monomeric beta-sheet proteins and novel biomaterials.
Novel proteins from designed combinatorial libraries