A historical perspective on ideas on X-chromosome inactivation
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| Format: | Electronic Video |
| Language: | English |
| Published: |
London :
Henry Stewart Talks,
2007.
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| Series: | Henry Stewart talks. Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms.
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| Subjects: | |
| Online Access: | https://hstalks.com/bs/107/ Series |
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Table of Contents:
- Contents: The phenomenon of X-chromosome inactivation in female mammals
- X-chromosome inactivation as a dosage compensation mechanism for equalising the dosage of X-linked gene products in XY males and XX females in somatic cells
- inactivity of either the maternal or paternal X-chromosome in different cells in eutherian mammals
- preferential inactivation of paternal X in the placenta of mice and in all cells of marsupials
- initiation of the process from an X-inactivation centre
- discovery of the key gene, Xist
- the concept of initiation and maintenance of X-inactivation as separate processes
- histone modifications and methylation of CpG islands as maintenance mechanisms
- inactivation in autosomal and X-chromosomal DNA
- LINE1s as booster elements on the X-chromosome.
A historical perspective on ideas on X-chromosome inactivation