Plasmacytoid dendritic cells sensing nucleic acids in viral infection and autoimmunity /
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| Format: | Electronic Video |
| Language: | English |
| Published: |
London :
Henry Stewart Talks,
2009.
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| Series: | Henry Stewart talks. Biomedical & life sciences collection. Innate immunity : host recognition and response in health and disease.
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| Subjects: | |
| Online Access: | https://hstalks.com/bs/1289/ Series |
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Table of Contents:
- Contents: Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection
- This function of pDCs is linked to their expression of Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids within the early endosomes
- Exclusion of self nucleic acids from TLR-containing early endosomes normally prevents pDC responses to them
- In some autoimmune diseases, self nucleic acids can be modified by host factors and gain entrance to pDC endosomes, where they activate TLR signaling
- Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis.
Plasmacytoid dendritic cells sensing nucleic acids in viral infection and autoimmunity /