Table of Contents:
  • Contents: Management of multi drug resistance (MDR) and extensive drug resistance (XDR) TB
  • Management of TB before era of drug treatment
  • Surgery for TB
  • Drug treatment was introduced from 1943-1963
  • Rifampicin (1963)
  • Timeline: discovery of drugs for TB
  • Emergence of totally drug resistant TB
  • Epidemiology
  • Outcomes of MDR-TB treatment
  • Survival curve of HIV patients with XDR TB
  • Current drug treatment
  • Treatment outcome in several cohorts
  • Death rates in several cohorts
  • Current approach for treatment of MDR/XDR TB
  • WHO's programmatic management of DR TB
  • Treatment recommendations
  • Group 1: oral first-line agents
  • Group 2: fluoroquinolones
  • Group 3: injectables
  • Group 4: less-effective anti-TB drugs
  • Group 5: less-effective or clinical data sparse drugs
  • Future drug treatment
  • New compounds
  • Bedaquiline (TMC207)
  • The nitroimidazoles
  • Thioridazine
  • NC-001 (PA-824, moxifloxacine, PZA)
  • Dreams and realities for the future of TB treatment.