Mitochondria and calcium signaling in cell life and cell death

Mitochondria and calcium signaling in cell life and cell death

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Bibliographic Details
Other Authors: Duchen, Michael R. (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2018.
Series:Henry Stewart talks. Biomedical & life sciences collection. Mitochondria in health and disease.
Subjects:
Calcium > Metabolism.
Calcium > Physiological effect.
Cell death.
Cellular signal transduction.
Mitochondria.
Calcium Metabolism Disorders.
Calcium Signaling.
Cell Death.
Cytosol > metabolism.
Mitochondria > metabolism.
Mitochondria > physiology.
Mitochondrial Membrane Transport Proteins.
mitochondrial permeability transition pore.
Neuromuscular Diseases.
Oxidative Phosphorylation.
Permeability.
Online Access:https://hstalks.com/bs/3684/
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Table of Contents:
  • Contents: Calcium signalling, ubiquitous and associated with increased energy demand
  • Mitochondria machinery to for taking up calcium from the cytosol
  • The transfer of calcium from cytosol to mitochondria (stimulation of oxidative phosphorylation & matching energy supply with demand)
  • Mutations in proteins that regulate mitochondrial calcium uptake (causation of a neuromuscular disease, possibly by mitochondrial calcium overload)
  • Acute severe calcium overload causes cell death during reperfusion of ischaemic tissues
  • The permeability transition pore, a potential therapeutic target.

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