Molecular biology of ryanodine receptors

Saved in:
Bibliographic Details
Other Authors: George, Christopher H. (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2007.
Series:Henry Stewart talks. Biomedical & life sciences collection. Calcium signaling I.
Subjects:
Online Access:https://hstalks.com/bs/405/
Series
Tags: Add Tag
No Tags, Be the first to tag this record!
Table of Contents:
  • Contents: Molecular cloning of RyR
  • The identification of functional domains
  • RyR channel structure
  • Channel regulation by: a) inter-RyR interaction, b) divalent cations and c) protein:protein interactions
  • The role of leucine zippers in assembling the 'macromolecular complex'
  • Defective protein:protein interactions in cardiac disease
  • Genetic basis of RyR dysfunction
  • Identification of mutations in cardiac RyR
  • Functional characterization of RyR mutations
  • Investigating interdomain interactions using state-of-the-art imaging tools
  • Pathological defects in channel stability.