Epigenetically mediated gene silencing a companion to genetic alterations in driving tumorigenesis /
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| Format: | Electronic Video |
| Language: | English |
| Published: |
London :
Henry Stewart Talks,
2007.
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| Series: | Henry Stewart talks. Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms.
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| Subjects: | |
| Online Access: | https://hstalks.com/bs/124/ Series |
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Table of Contents:
- Contents: Introduction to epigenetic changes in cancer
- defining the process of promoter DNA hypermethylation as a constituent of a broad range of chromatin abnormalities in cancer
- defining the genes aberrantly silenced in cancer including approaches being used to screen the cancer genome for such genes
- defining what is known about the interaction of DNA methylation and chromatin modifications for initiating and maintaining gene silencing in cancer
- outlining the position of aberrant gene silencing in tumor progression and particularly highlighting the key role these changes may play for the earliest steps in tumorigenesis
- defining the potential for using DNA hypermethylated gene promoter sequences as molecular markers for cancer risk assessment, early diagnosis and prognosis
- discussing the possibilities for targeting reversal of gene silencing as a prevention and therapeutic strategy for cancer.
Epigenetically mediated gene silencing a companion to genetic alterations in driving tumorigenesis /