Drug-induced liver disease an update for 2010 /

Drug-induced liver disease an update for 2010 /

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Bibliographic Details
Other Authors: Lewis, James H. (Speaker)
Format: Electronic Video
Language:English
Published: London : Henry Stewart Talks, 2011.
Series:Henry Stewart talks. Biomedical & life sciences collection. Gastroenterology and hepatology.
Subjects:
Drug-Induced Liver Injury.
Gastroenterology.
Online Access:https://hstalks.com/bs/1916/
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Table of Contents:
  • Contents: DILD overview
  • Pathology of DILD
  • Incidence of DILI
  • Spectrum of DILI
  • Hepatic adverse event nomenclature: liver injury
  • Causes of acute liver failure
  • Biochemical patterns of liver injury
  • Clinical features of acute hepatocellular DILD
  • Cholestatic DILI
  • Drugs associated with chronic autoimmune type hepatitis
  • Drugs associated with hepatic fibrosis/cirrhosis
  • Drug-induced steatohepatitis
  • Miscellaneous forms of chronic DILD
  • Prevalence of hepatic enzyme elevations with various drugs
  • Possible mechanisms of drug adaptation (drug tolerance)
  • Drugs that have caused fulminant hepatic failure
  • FDA stopping rule for liver injury in drug development
  • Mortality from acute DILD
  • Hy's law
  • Causes of drug induced ALF leading to liver transplant
  • Major regulatory actions due to DILI
  • Drug related and idiosyncratic mechanisms of cellular injury in DILI
  • Drug metabolism and risk of DILI
  • Acetaminophen association with DILI
  • Host risk factors for DILD
  • Possible genetic predisposition to DILD
  • Alcohol and other agents that affect drug hepatotoxicity
  • Medicating patients with underlying liver disease
  • The importance of accurately diagnosing DILI
  • Improving the causality assessment process using scoring systems
  • Preventing drug induced liver disease
  • Treating DILD
  • Herbal agents (problems and use)
  • DILI risk vs. benefit considerations
  • Future directions in DILD.

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