Drug-induced liver disease an update for 2010 /
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Format: | Electronic Video |
Language: | English |
Published: |
London :
Henry Stewart Talks,
2011.
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Series: | Henry Stewart talks. Biomedical & life sciences collection. Gastroenterology and hepatology.
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Subjects: | |
Online Access: | https://hstalks.com/bs/1916/ Series |
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Table of Contents:
- Contents: DILD overview
- Pathology of DILD
- Incidence of DILI
- Spectrum of DILI
- Hepatic adverse event nomenclature: liver injury
- Causes of acute liver failure
- Biochemical patterns of liver injury
- Clinical features of acute hepatocellular DILD
- Cholestatic DILI
- Drugs associated with chronic autoimmune type hepatitis
- Drugs associated with hepatic fibrosis/cirrhosis
- Drug-induced steatohepatitis
- Miscellaneous forms of chronic DILD
- Prevalence of hepatic enzyme elevations with various drugs
- Possible mechanisms of drug adaptation (drug tolerance)
- Drugs that have caused fulminant hepatic failure
- FDA stopping rule for liver injury in drug development
- Mortality from acute DILD
- Hy's law
- Causes of drug induced ALF leading to liver transplant
- Major regulatory actions due to DILI
- Drug related and idiosyncratic mechanisms of cellular injury in DILI
- Drug metabolism and risk of DILI
- Acetaminophen association with DILI
- Host risk factors for DILD
- Possible genetic predisposition to DILD
- Alcohol and other agents that affect drug hepatotoxicity
- Medicating patients with underlying liver disease
- The importance of accurately diagnosing DILI
- Improving the causality assessment process using scoring systems
- Preventing drug induced liver disease
- Treating DILD
- Herbal agents (problems and use)
- DILI risk vs. benefit considerations
- Future directions in DILD.