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Mass spectrometry in drug metabolism and disposition basic principles and applications /

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"This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to...

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Bibliografiske detaljer
Institution som forfatter: ebrary, Inc
Andre forfattere: Lee, Mike S., 1960-, Zhu, Mingshe
Format: Electronisk eBog
Sprog:engelsk
Udgivet: Hoboken, N.J. : John Wiley & Sons, c2011.
Serier:Wiley series on pharmaceutical science and biotechnology: practices, applications and methods
Fag:
Drugs > Metabolism > Analysis.
Metabolites > Spectra.
Mass spectrometry.
Electronic books.
Online adgang:An electronic book accessible through the World Wide Web; click to view
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Indholdsfortegnelse:
  • (Publisher-supplied data) Part I Basic Concepts of Drug Metabolism and Disposition
  • The Progression of Drug Metabolism
  • Common Biotransformation Reactions
  • Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry
  • Drug Metabolizing Enzymes, Transporters and Drug-Drug Interactions
  • Experimental Models of Drug Metabolism and Disposition
  • Principles of Pharmacokinetics: Predicting Human Pharmacokinetics
  • Drug Metabolism Research as an Integral Part of the Drug Discovery and Development Processes
  • Part II Mass Spectrometry in Drug Metabolism: Principles and Common Practice
  • Theory and Instrumentation of Mass Spectrometry
  • Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification
  • Mass Spectral Interpretation
  • Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography and Non-Mass Spectrometric Detection
  • Part III Applications of New LC/MS Techniques in Drug Metabolism and Disposition
  • Quantitative In Vitro ADME Assays using LC-MS as a Part of Early Drug Metabolism Screening
  • High Resolution Mass Spectrometry and Drug Metabolite Identification
  • Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging
  • Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC/MS Platform in Drug Metabolism and Pharmacokinetics Studies
  • Quantitative Drug Metabolism with Accelerator Mass Spectrometry
  • Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions
  • Profiling and Characterization of Herbal Medicine and their Metabolites using LC-MS
  • Liquid Chromatography Mass Spectrometry Bioanalysis of Proteins in Biological Matrices
  • Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress
  • LC-MS in Endogenous Metabolite Profiling and Small Molecule Biomarker Discovery.

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