Gene discovery for disease models
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| Médium: | Elektronický zdroj E-kniha |
| Jazyk: | angličtina |
| Vydáno: |
Hoboken, N.J. :
Wiley,
c2011.
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| Témata: | |
| On-line přístup: | An electronic book accessible through the World Wide Web; click to view |
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Obsah:
- Introduction : gene discovery-from positional cloning to genomic cloning
- High throughput gene expression analysis and the identification of expression QTLs
- DNA methylation in the pathogenesis of autoimmunity
- Ccell-based analysis with microfluidic chip
- Missing dimension : protein turnover rate measurement in gene discovery
- Bioinformatics tools for the prediction of gene function
- Determination of genomic locations of targeted genetic loci
- Mutation discovery using high throughput mutation screening technology
- Candidate screening through gene expression profile
- Candidate screening through high-density SNP array
- Gene discovery through direct genome sequencing
- Candidate screening through bioinformatics tools
- Using an integrative strategy to identify mutations
- Determination of the function of a mutant in a gene
- Confirmation of a mutation by multiple molecular approaches
- Confirmation of a mutation by microRNA
- Confirmation of function of a gene by translational approaches
- Confirmation of single nucleotide mutations
- Initial identification and confirmation of a QTL gene
- Gene discovery of crop diseases in the post genome era
- Impact of whole genome genetic element analysis on gene discovery of disease models
- Impact of whole genome protein analysis on gene discovery of disease models.