Shu Chien (; born June 23, 1931) is a Chinese–American physiologist and bioengineer. His work on the fluid dynamics of blood flow has had a major impact on the diagnosis and treatment of cardiovascular diseases such as atherosclerosis. More recently, Chien's research has focused on the mechanical forces, such as pressure and flow, that regulate the behaviors of the cells in blood vessels. Chien is currently President of the Biomedical Engineering Society.