11β-hydroxysteroid dehydrogenase-1 deficiency alters the gut microbiome response to Western diet

11β-hydroxysteroid dehydrogenase-1 deficiency alters the gut microbiome response to Western diet

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The enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD) interconverts active glucocorticoids and their intrinsically inert 11-keto forms. The type 1 isozyme, 11β-HSD1, predominantly reactivates glucocorticoids in vivo and can also metabolise bile acids. 11β-HSD1-deficient mice show altered inflammator...

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Bibliografiske detaljer
Main Authors: Jethro, S Johnson, Opiyo, Monica N, Thomson, Marian, Karim, Gharbi, Andreas, Heger, Chapman, Karen E
Format: Article
Sprog:English
Udgivet: The Journal of Endocrinology 2019
Fag:
Glucocorticoids
11β-HSD
Diet
Gut microbiome
Online adgang:https://repository.daystar.ac.ke/handle/123456789/2965
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https://repository.daystar.ac.ke/handle/123456789/2965

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