11β-hydroxysteroid dehydrogenase-1 deficiency alters the gut microbiome response to Western diet
The enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD) interconverts active glucocorticoids and their intrinsically inert 11-keto forms. The type 1 isozyme, 11β-HSD1, predominantly reactivates glucocorticoids in vivo and can also metabolise bile acids. 11β-HSD1-deficient mice show altered inflammator...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artikel |
| Taal: | English |
| Gepubliceerd in: |
The Journal of Endocrinology
2019
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| Onderwerpen: | |
| Online toegang: | https://repository.daystar.ac.ke/handle/123456789/2965 |
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Immunology, the microbiome and future perspectives